Annette (2021)

Looking at the title an some of the images from the film that feature a creepy doll, it’s easy to assume that this is a horror movie of some kind. Yet things aren’t so straightforward as this is a musical using music entirely by the Sparks brothers and is directed by Leos Carax, whose last film Holy Motors I found almost completely incomprehensible. Some bizarreness aside, the main plot, once it gets going, is actually quite straightforward and emotionally affecting. The involvement of the Sparks brothers makes it unique and sometimes makes it feel more like performance art than a film.

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Nobel Prizes 2022

Every year I write a summary of the Nobel Prize winners in the sciences and in economics. Sometimes however the achievements in the sciences may be so esoteric that I struggle to understand what the prize is for. That isn’t the case this year are the winners are either very famous discoveries or quite straightforward to make sense of.

We start with the prize for physics for discoveries that most of us have already heard about one way or another but are so badly explained even in respectable publications. This refers to the phenomenon of quantum entanglement in which particles can be entangled with one another such that what happens to one particle can determine what happens to another no matter how far they are apart. Albert Einstein was notoriously skeptical that this could seemingly violate the speed of light limit.

Building on the ideas of John Stewart Bell to tell the difference between whether the strange entanglement effect truly exists or if there are hidden variables that determine what happens, John Clauser built a practical experiment that showed that such hidden variables probably don’t exist. A loophole remained however which was closed by the second laureate Alain Aspect by switching the measurement settings of the experiment after the entangle pair had left the source to prove that the setting could not affect the result.

Finally the third laureate Anton Zeilinger exhibited the phenomenon of quantum teleportation which involves moving the quantum state of a particle to another at a distance. This is the basis of quantum computing and quantum cryptography.

The prize for physiology or medicine goes to Svante Pääbo who essentially founded the field of paleogenomics. This is the study of the genomes of ancient, perhaps extinct, biological species. Extracting and sequencing ancient DNA has been known to just about everyone since Jurassic Park but the reality is more difficult as DNA degrades over time and samples tend to be contaminated by bacteria and contemporary organisms. So Pääbo began by studying the mitochondrial DNA of Neanderthals as they are small and thousands of copies are present in each cell.

As technology and his own techniques improves, he also sequenced the nuclear DNA of Neanderthals, allowing comparative analyses with the DNA of modern humans. He was later also able to identify a completely new species Homo denisova from DNA evidence alone. He showed that this species interbred with Homo sapiens and helped establish ancient migration patterns.

I think the research that went into the prize for chemistry is the least well known of the lot to the general public but it’s not really hard to understand either. Barry Sharpless, for whom this is the second Nobel Prize, and Morten Meldal conceived and created a mechanism to implement what is now called click chemistry. In chemistry, you often want to snap different groups of molecules together and you want a joining process that works regardless of the chemical properties of each group. These two laureates, working independently, came up with the process called the copper catalysed azide-alkyne cycloaddition that used copper ions to speed up the previously known process of using two groups of chemicals azides and alkynes to snap together like buckles and reduce unwanted byproducts.

However copper ions are toxic to living things, making this process unsuitable for purposes like making pharmaceuticals. The third laureate Carolyn Bertozzi therefore invented a new way to make the process work without copper ions. Her idea was to put the alkyne half of the buckle under strain to make it more reactive. She used it to attach fluorescent marker molecules to carbohydrate polymers on the surface of cells, allowing them to be more easily tracked as they move about the body. Her version of the process is called bioorthogonal reactions.

Finally the prize in the economic sciences goes to Ben Bernanke, Douglas Diamond and Philip Dybvig for their studies of financial crises and the banking system’s role in them. Diamond and Dybvig showed that banks are intermediaries between savers and borrowers, which sounds simple enough but by pooling many deposits, banks are able to offer long-term loans to borrowers to support investments while also assuring depositors that they can access their funds at need. This however only works if the banks are trusted to be sound and the system is at risk of a bank run if depositors try to withdraw their money en masse.

Bernanke is of course well-known as the chairman of the Federal Reserve during the financial crises of 2007-2008 but it is his work in studying the Great Depression that was cited for the prize. He showed that the banks were not just a victim of the crisis, but when banks failed, the loss of information about borrowers contributed to prolonging the crisis. As The Economist noted, these insights seem like fairly obvious ones but I suppose the formal, academic treatment of the subject is valuable.

Slay the Spire

Anyone who knows anything about videogaming doesn’t have to be told how popular this was a while back. It turned out to be highly influential as well as many other games have since copied its simple yet highly addictive design. I never picked it up back then because I hate rogue-likes and the art it uses looked basic to me. But I always knew that I would probably enjoy this somewhat due to my love for deckbuilding mechanics and this is too important of a cultural touchstone to ignore forever. Having put some time into this now, I can say that it really is absolutely brilliant and I was an idiot for putting it off so long.

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Night of the Kings (2020)

I’ve never have thought that the Ivory Coast but this film by director Philippe Lacôte is truly remarkable. Not only does it effectively showcase some of his people’s culture, it throws a bit about the country’s political turmoil and references some of the most ancient traditions of storytelling. All this plus it’s such a gorgeous film to boot! I’m not sure that the plot makes much sense and this certainly is in no way a real prison but that doesn’t matter at all as the film draws us into a world of its own that runs on its own rules.

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Cape Fear (1962)

This is a very shocking thriller on many levels and understandably ran into a lot of trouble with the censors of its era with its allusions to child rape. The main villain is unambiguously menacing and towards the end of the film truly monstrous, yet I liked the film more at the beginning when there was some doubt as to whether or not the protagonist is justified in deploying the full force of the law against the antagonist. I suppose it’s because times have changed so much that someone who a figure of authority invoking the law on his side is more frightening than a lone heinous criminal. While this ends up being a film that ramps up the tension effectively, I don’t like it much at all as I think it is both implausible and wants to deliver the wrong lessons.

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The Power of the Dog (2021)

So we finally get around to this, the film that was considered to be badly snubbed at this year’s Oscars, garnering 12 nominations but winning only one for Jane Campion as best director. I think this is a fair accusation given how the actual winners were mostly such safe choices and this film can be interpreted as a direct attack on the archetype of the Western cowboy. I have my issues with how it seems so unbalanced in terms of character development but my wife and I had plenty to discuss about it afterwards and that’s always a sure sign of an interesting film.

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Artificial Condition

Last year, I mentioned how the popular Murderbot Diaries series seems to make for a fairly entertaining read but it would be too expensive to buy each novella one by one. Then I realized that the series is available for reading on Kindle Unlimited which is cheap to get so now I can finally get the whole story. This is the second of a total of four parts that I believe should round out what amounts to the first book if it were published in a more traditional format.

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The unexamined life is a life not worth living